Why It Works: Mechanism of Action
i-Rebuild® combines precision-selected probiotic strains with cell-supportive cofactors to repair, protect, and revitalize at the cellular level.
Proudly Made in Hong Kong, our formulation marries cutting-edge science with natural care.
Proudly Made in Hong Kong — Repair at the Cellular Level
Six-Strain Probiotic Blend
(Functional Role) Core Efficacy Engine
Mechanism of Action
- Barrier integrity: Supports occludin/claudins and mucin to reduce gut permeability.
- Microbial balance: Competitive exclusion of harmful species; organic acids lower luminal pH.
- Postbiotic signaling: Short-chain fatty acids (esp. butyrate) modulate NF-κB and fuel mucosal repair.
- Immune modulation: Stimulates sIgA & T-reg cells for calm, balanced immune responses.
- Motility & comfort: Supports predictable intestinal transit and digestive comfort.
*Educational statements only; not intended to diagnose, treat, cure, or prevent disease.
Bifidobacterium longum BB536™
(Functional Role) Gut Health Foundation
Mechanism
- Strengthens tight-junction proteins and mucin for epithelial barrier integrity.
- Produces acetate and SCFAs to nourish colonocytes & balance pH.
Literature Support (Representative)
Matsumoto et al., 2011 — Beneficial Microbes
Lactobacillus acidophilus NCFM®
(Functional Role) Harmful Bacteria Inhibitor
Mechanism
- Provides competitive exclusion; secretes organic acids/bacteriocins to maintain healthy pH.
- Enhances sIgA and epithelial immune crosstalk.
Literature Support (Representative)
Altermann et al., 2005 — PNAS
Bifidobacterium lactis Bi-07®
(Functional Role) Immune Specialist
Mechanism
- Trains innate and adaptive immune pathways.
- Promotes balanced cytokine signaling and sIgA production.
Literature Support (Representative)
Dong et al., 2013 — Journal of Nutrition
Bifidobacterium lactis HN019™
(Functional Role) Digestive Motility Support
Mechanism
- Associated with improved colonic transit time and regularity.
- SCFA-mediated signaling enhances enteric nervous system comfort.
Literature Support (Representative)
Waller et al., 2011 — Scandinavian Journal of Gastroenterology
Lactobacillus rhamnosus HN001™
(Functional Role) Barrier & Mood Guardian
Mechanism
- Supports epithelial barrier function.
- Modulates gut–brain communication (via GABA, tryptophan metabolism, and vagal pathways).
Literature Support (Representative)
Wickens et al., 2018 — J Allergy & Clinical Immunology
Lactobacillus plantarum Lp-115®
(Functional Role) Anti-inflammatory Balancer
Mechanism
- SCFA and postbiotic signaling temper NF-κB activity.
- Supports antioxidant enzyme systems and cellular redox balance.
Literature Support (Representative)
Arena et al., 2018 — Frontiers in Microbiology
*These statements are for educational purposes only and are not intended to diagnose, treat, cure, or prevent any disease.
Always follow label directions and consult a healthcare professional.